ABSTRACT
Hereditary hemorrhagic telangiectasia (HHT) of Rendu-Osler-Weber disease is a multi system vascular dysplasia characterized by the presence of multiple telangiectasias, mainly affecting mucosal tissue and arterial-venous connections. It commonly affects lungs, liver and central nervous system. Bleeding is the most common symptom and its treatment can be surgical or pharmacological. We herein review the systemic therapy that attempts to minimize bleeding as well as blood transfusion therapy. Blood therapy and fibrinolytic treatment especially aminocaproic acid and tranexamic acid are discussed. Danazol, hormone therapy and other less common drugs used in the treatment of HHT are also reviewed.
Subject(s)
Humans , Telangiectasia, Hereditary Hemorrhagic/therapy , Antifibrinolytic Agents/therapeutic use , Blood Transfusion , Hormones/therapeutic use , Tranexamic Acid/therapeutic useABSTRACT
Streptococcus constellatus is a commensal microorganism in man but may cause infections in different locations. We report a 59 years old male with severe sequelae of a previous cerebrovascular accident that consulted in the emergency room for fever of 15 days of evolution. A right empyema was diagnosed. The bacteriological culture of the effusion disclosed the presence of Streptococcus constellatus and two anaerobic strains (Prevotella intermedia and Fusobacterium urealyticus). The patient was treated with a pleural drainage and received ceftriaxone and clindamycin during six weeks. He was discharged in good conditions and is asymptomatic after eight months of follow up.
Subject(s)
Humans , Male , Middle Aged , Empyema, Pleural/microbiology , Streptococcal Infections/complications , Streptococcus constellatus , Drainage , Empyema, Pleural/therapy , Streptococcal Infections/therapy , Stroke/complicationsABSTRACT
El absceso esplénico es una entidad poco frecuente, que presenta dificultad diagnóstica y tiene alta letalidad si no se trata. Se estima que la enfermedad está en aumento en relación al incremento en el número de pacientes inmunocomprometidos. Varios serían los mecanismos implicados en su patogenia. Algunos estudios muestran la preexistencia de lesiones esplénicas sumadas a bacteriemia como necesarios en su génesis. En nuestra serie se identificaron 9 pacientes inmunocompetentes en un período de 6 años. Entre los patógenos se aislaron Salmonella sp, Staphyloccus sp y Enterococcus sp. En tres casos se realizó esplenectomía, y en uno se efectuó drenaje percutáneo. Un paciente falleció. En definitiva, aunque infrecuentes, los abscesos esplénicos presentan una gran morbimortalidad. Factores de riesgo como inmunodeficiencia no son tan prevalentes en nuestra experiencia, debiéndose considerar esta patología en la evaluación completa de los pacientes con fiebre de origen no precisado.